Latest Research on Canker Sore Treatments

It may be somewhat surprising to learn that in spite of ongoing research, no one know the exact cause of aphthous ulcers, also know as recurrent aphthous stomatitis (RAS) and more commonly known as canker sores. These are small ulcers that can appear inside the mouth and cause a lot of pain and annoyance until they heal, which can take up to 10 days. Some theories offer up genetics, autoimmune issues and allergies as possible causes. There have been a number of research studies that have looked at possible treatments for mouth sores, as well as some potential causes. Here are a few interesting possibilities.

Immune System Research

Researchers are attempting to pinpoint what kind of blips in the immune system could make some people more likely to get chronic canker sores. Scientists have analyzed the blood of patients with and without mouth ulcers and it appears there are some differences in the way their immune systems function. Unfortunately, they have not yet been able to determine just how this affects RAS just yet.

New Medication

A new anti-inflammatory and anti-allergic drug called amlexanue is currently being tested and shows some promise in treating canker sore symptoms and aiding  in healing.

Licorice Root Extract Shows Promise

In a 2008 study canker sore sufferers placed a dissolving patch containing licorice root extract called deglycyrrhizinated licorice or DGL over their mouth sores. The researchers found that 80 percent of participants achieved significant pain relief very quickly and healing in just three days.  These patches are available over-the-counter in drug stores in a product called Cankermelts Medicated Discs.

SLS-free Toothpaste

A study* measuring the incidence of RAS using toothpastes with and without sodium laurel sulfate (SLS) was conducted using a single-blind crossover design. Researchers found that subjects that used an SLS-free toothpaste achieved a statistically significant reduction in canker sores during the two months of use compared to two months using toothpaste with SLS. These results support earlier research, indicating people susceptible to recurring mouth sores may benefit by switching to an SLS-free toothpaste. There are a number of toothpastes available without this ingredient, which is a detergent and foaming agent widely used in toothpastes, mouthwash, shaving cream, shampoo, body wash and many other personal care products. Recommended toothpastes include Biotene , Rembrandt Gentle White Toothpaste, and Tom’s of Maine Clean and Gentle Care

Laser Treatment

In the past the only alternatives for treating canker sores were over-the-counter products and home remedies that produced a variety of results, but  most of which weren’t great for speeding healing.  Prescription drugs were and still are sometimes used, but they can produce undesirable side effects. Now canker sores can be treated quickly and painlessly with a laser. In addition to preventing the mouth sore from growing bigger, it dramatically speeds the healing process.  Dentists report that in many instances the ulcer disappears ten days faster than it would if it had not been treated by the laser. Therefore, if you suffer from frequent painful mouth sores it pays to have the laser treatment as soon as your sore first appears. The treatment takes under 15 minutes at your dentist’s office. Not all dentists offer this treatment as this is fairly new, so you may need to do some research of your own to see what dentists in your area offer laser. The other downside is that it could be costly, but if you are in agony, it could be worthwhile pursuing.

Daily Multivitamin Ineffective

Earlier research indicated that people with vitamin deficiencies, particularly Vitamin B12, folic acid, zinc and iron, were more susceptible to canker sores. A new study published in the April issue of the Journal of the American Dental Association in April 2012, however, found that taking a daily multi-vitamin did not provide any benefit, i.e. study participants prone to recurrent aphthous ulcers (RAS) did not experience a reduction in frequency of outbreaks.  There were 160 people with minor RAS in the one-year research study. There were 83 in the study group and 77 in control group; the study group got a multivitamin with 100% of the RDI. Members of both groups had an average of four canker sore outbreaks of about eight days in length. There was no difference in pain levels among the two groups.

Vitamin B12 Can Be an Effective Treatment

It should be noted that the RDI for Vitamin B12 is only 2.4 mcg, so that was the amount in the daily multi-vitamin given to the study participants referenced above. It may be that the multivitamin did not contain enough Vitamin B12 to be effective.  In another study by physicians as Ben-Gurion University of the Negev, it was found that a nightly dose of 1000mcg of Vitamin B12 was found to be an effective treatment for preventing canker sores. Of the study participants who received the B12, they had  less pain, fewer canker sores, and sores did not last as long versus the control group.




4 comments for “Latest Research on Canker Sore Treatments

  1. kidane
    May 7, 2013 at 10:54 pm

    I am suffering by canker sore from my childhood until now.I am now 34 years old. I went to doctors countless times for this disease, but I didn’t get any medicine that helps me for this disease.recently I went to ENT doctor & he gave me B complex vitamin & men’s health multivitamin/mineral, I took them for 3 month,I feel little bit better.But when I get hard time like physical work, they got back again.Now I have 3 to 4 sores in my mouth.I am trying to pray if I can get solution from GOD.

    • Steve Kasian
      October 13, 2019 at 10:32 pm

      I suffer from them as well, but only periodically. My mother had (and still has) them bad, all her life. When she was in her 30s and 40s, she would get 5-8 in her mouth at once, some of them being as big as her pinkie fingernail, and couldn’t eat or sleep for says at a time. I don’t know how she put up with it without ending it all, as I could never stand that much pain for so long; But she’s mom, and women are able to deal with the pain of childbirth, so there you go! I appreciate your pain and hope that they find a cure for us soon! My mother has found that using Mentholatum on them seems to help make them go away faster, by as much as a few days. It hurts like hell to apply it, but she swears by it as a remedy… and she’s been dealing with them for 80+ years, so she ought to know. I’ve tried it myself and found that it helps. Give it a shot! Good luck!

  2. Marty
    June 23, 2013 at 6:24 am

    I am also a lifelong sufferer, from 5 to 67. I’ve tried everything, and lysine worked for a while and then was ineffective. Same with eating lots of yogurt. Still searching. I never am without a canker sore or two, they are constant. To make it worse, (for about 10 years now) I get flu-like symptoms, which causes headache, sore throat, feverish feeling, (no fever) light headedness, and exhaustion, not to mention the excruciating pain, so I spend time in bed. I lose days every month. I haven’t been to doctors recently, because they dismiss it as inconsequential. But I’m doing research and will try with doctors again. Good luck to you, kidane.

  3. Javier
    April 2, 2017 at 5:03 am

    I started Devloping canker sore when I was about 19 years old. I was suffering for 12 years. I finally cut gluten out my diet and since then I rarely get them. Usually get them if I eat any cross contaminated gluten food ( bread, etc..). I every get now if my wife eats gluten and kiss me right away.

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